Colts vs. Titans 2025 Prediction, Odds, and Picks
Updated October 26, 2025, 12:43 p.m. 777sm pub ET
The Indianapolis Colts (6-1) will be looking to extend their three-game winning streak against the Tennessee Titans (1-6). The Colts are heavily favored, expected to win by two touchdowns or more with a spread currently sitting at -14.5. The total points for this matchup is set at 48.5.
Colts vs. Titans Odds & Betting Lines
Colts vs Titans Betting Information as of October 26, 2025, 12:33 p.m. ET:
- Favorite: Colts -14.5
- Favorite Spread Odds: -121
- Underdog Spread Odds: -110
- Total Over: 48.5 -103
- Total Under: 48.5 -129
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Colts vs. Titans Prediction & Pick
Pick ATS: Colts (-14.5)
Pick OU: Under (48 22win register.5)
Prediction: Colts 36 – Titans 11
How to Watch Indianapolis vs. Tennessee
Game Date: Sunday, October 26, 2025
Time: 4:25 p.m. ET
Venue: Lucas Oil Stadium
Location: Indianapolis, Indiana
TV: CBS
Live Boxscore: FOX Sports
Colts vs. Titans Recent Matchups
Indianapolis boasts a perfect 5-0 record against Tennessee in their last five encounters. Over these contests, the Colts have scored a total of 153 points, while the Titans have managed just 111.
Indianapolis Betting Info
The Colts have secured five wins against the spread this year out of seven games. Their matches have hit the over 57.1% of the time (four times in seven games with a set point total). 777 ph bet The Colts have triumphed in all four games where they were moneyline favorites this season, boasting a 94.1% chance of winning based on the implied probability of the moneyline.
Colts Stats
| Stat | Average (Total) | Rank |
|---|---|---|
| Pass Yards | 250.1 (1,751) | 5 |
| Rush Yards | 130.1 (911) | 7 |
| Points Scored | 33.1 (232) | 1 |
| Pass Yards Against | 255.4 (1,788) | 29 |
| Rush Yards Against | 90.3 (632) | 6 |
| Points Allowed | 20.0 (140) | 8 |
Indianapolis’ Key Players
Offense
Jonathan Taylor has been phenomenal on the ground, averaging 5.3 yards per attempt (fourth in the NFL), with a total of 697 rushing yards and 10 rushing touchdowns this season. In the receiving game, he’s caught 23 passes for 185 yards and one touchdown.
Quarterback Daniel Jones has accumulated 1,790 passing yards (fifth in the NFL), with 10 touchdowns and three interceptions while completing 71% of his passes.
Tight end Tyler Warren has contributed significantly with three touchdown catches and 33 receptions for 439 yards, while Michael Pittman Jr. has 351 receiving yards and five touchdowns.
Defense
On the defensive side, Nick Cross leads the team with 53 tackles and one interception. DeForest Buckner contributes with 36 tackles and three sacks this season, while Zaire Franklin has one sack and 42 tackles.
Tennessee Betting Info
Tennessee has covered the spread only twice this season (2-5-0). The Titans have played seven times as underdogs this season, securing just one victory viphh. The implied moneyline gives the Titans a mere 10.0% chance at winning this matchup.
Titans Stats
| Stat | Average (Total) | Rank |
|---|---|---|
| Pass Yards | 159.9 (1,119) | 31 |
| Rush Yards | 75.7 (530) | 31 |
| Points Scored | 13.7 (96) | 32 |
| Pass Yards Against | 210. bk8 trang0 (1,470) | 14 |
| Rush Yards Against | 139.6 (977) | 29 |
| Points Allowed | 27.4 (192) | 28 |
Tennessee’s Key Players
Offense
Running back Tony Pollard leads the Titans with 380 rushing yards and two rushing touchdowns, averaging 54.3 yards per game. Quarterback Cameron Ward has posted 1,356 passing yards with four touchdowns and five interceptions this season.
Receiver Elic Ayomanor has caught 19 passes for 225 yards and two touchdowns, while Calvin Ridley stands at 290 receiving yards without a touchdown thus far.
Defense
Defensively, Jeffery Simmons leads with 30 tackles and 4.5 sacks, while Cedric Gray has a total of 66 tackles this season. Amani Hooker has also made significant contributions with 36 tackles and two TFLs.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar. Are you excited about this upcoming showdown between the Colts and Titans?